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Health

Medications and the Heat: A Risky Combination

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As temperatures rise, it’s crucial to understand how certain medications can impact your body’s ability to regulate its temperature. For many, especially older adults, these medications can increase the risk of heat-related illnesses, even death.

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The Pharmacy Team at St. Luke’s Health-The Vintage Hospital has compiled this comprehensive overview so people can understand how medication impacts their ability to handle these hot summer temperatures.

How Your Body Cools Down

Your body maintains a core temperature of around 98.6 degrees Fahrenheit through two primary mechanisms:

  • Sweating: Evaporation of sweat cools the skin.
  • Vasodilation: Blood vessels near the skin widen, bringing warm blood to the surface to release heat.
As temperatures rise, it’s crucial to understand how certain medications can impact your body’s ability to regulate its temperature; Photo Courtesy St. Luke’s Health-The Vintage Hospital

Medications That Can Interfere with Cooling

Several common medications can disrupt these cooling processes. See below for a full breakdown:

Type of medicationExamplesDisruptions to cooling processes
Heart beta blockersToprol or LopressorReduce thirst, leading to dehydration
Heart ACE inhibitorsZestrill or PrinivilReduce thirst, leading to dehydration
Agiotensein II receptor blockersCozaar or DiovanReduce thirst, leading to dehydration
AntiplateletsPlavixReduce thirst, leading to dehydration
DiureticLasixIncrease urination, potentially leading to dehydration
Antidepressants – Selective Serotonin Reuptake Inhibitors (SSRIs)Celexa, Lexapro, Prozac or ZoloftImpair sweating
Antidepressants – Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)Cymbalta or Effexor XRImpair sweating
Tricyclic antidepressantsElavil or PamelorImpair sweating
AntipsychoticsHaldol or SeroquelInterfere with thermoregulation
ADHD medicationsAdderall or RitalinIncrease body temperature
Anticholinergics, often prescribed for Parkinson’s disease and overactive bladderCogentin or DitropanInhibit sweating
AntihistiminesBenadrylReduce sweating
DecongestantsSudafed, Afrin, Zicam or MucinexRaise body temperature
Dopaminergics, often prescribed for Parkinson’s diseaseSinemetInterfere with thermoregulation


Medications That Increase Sunburn Risk

Certain medications can make your skin more sensitive to the sun:

  • Antibiotics: Tetracycline or Doxycycline
  • Antifungals: Gris-PEG
  • Antihistamines: Claritin or Zyrtec
  • Statin Cholesterol Medications: Lipitor, Zocor or Mevacor
  • Diabetes Medications: Glucotrol or Micronase

If you take any of these medications, use sunscreen with SPF 30 or higher, reapply frequently, and consider sun-protective clothing and hats.

Tips for Staying Safe in the Heat

  • Consult Your Doctor: Never stop taking medication abruptly. Discuss your concerns with your doctor.
  • Proper Storage: Store medications as directed, as heat can reduce their effectiveness.
  • Hydration is Key: Drink plenty of fluids, especially water. Dark urine is a sign of dehydration. Consult your doctor if you are on fluid restriction. Avoid alcohol.
  • Stay Cool: Wear loose, light-colored clothing, use fans or air conditioning, and avoid strenuous activity during peak heat hours.
  • Know the Signs: Be aware of heat exhaustion and heat stroke symptoms (dizziness, confusion, excessive sweating) and seek medical attention if needed.
  • Understand Your Medications: Know the potential side effects of your medications and ask your doctor about heat-related risks.


By understanding the risks and taking precautions, you can stay safe and healthy while managing your medications during hot weather.

It is crucial to consult with a qualified physician or healthcare professional for any medical questions, concerns, or before making any decisions related to your health or treatment.

St Luke’s The Vintage Hospital @ 20171 Chasewood Park Dr, Houston, TX 77070; Photo Credit: St. Luke’s Health-The Vintage Hospital

To learn more about St. Luke’s Health-The Vintage Hospital, please click here.

Source: St. Luke’s Health-The Vintage Hospital

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